What Not to Take with Lansoprazole

Lansoprazole is a proton pump inhibitor commonly prescribed to reduce stomach acid production. It is used to treat conditions such as gastroesophageal reflux disease (GERD), stomach ulcers and Zollinger-Ellison syndrome. While lansoprazole is generally safe and effective, it can interact with certain medications and substances, potentially affecting how it works or increasing the risk of side effects. Understanding what not to take with lansoprazole helps ensure its safe and effective use.

Medications That May Interact with Lansoprazole

Certain medications can interact with lansoprazole and alter its absorption or effect. For example, drugs such as ketoconazole and itraconazole, which require an acidic stomach environment to be absorbed properly, may become less effective when taken with lansoprazole because it reduces stomach acid. Similarly, the absorption of iron salts can be decreased, potentially impacting the treatment of iron deficiency.

Lansoprazole can also affect how the body processes medications metabolised by the liver enzyme CYP2C19. This includes drugs like clopidogrel, an antiplatelet medication, where lansoprazole may reduce its effectiveness. Warfarin, a blood thinner, and diazepam, a medication used for anxiety and seizures, can also be affected, so close monitoring is recommended if these are taken concurrently.

Certain other medications, including digoxin, methotrexate, and certain antivirals, may have altered blood levels when taken with lansoprazole, which can increase the risk of side effects or reduce treatment effectiveness.

Other Considerations

Apart from medications, it is important to avoid excessive alcohol consumption while taking lansoprazole, as alcohol can irritate the stomach lining and counteract the benefits of the medication.

Advice for Safe Use

It is always advisable to inform your healthcare provider about all medications, supplements and over-the-counter products you are taking before starting lansoprazole. They can provide guidance on safe combinations and monitor for any interactions.

Summary

Lansoprazole can interact with a range of medications including antifungals, iron supplements, blood thinners, and certain anxiety or antiviral drugs. Avoiding these combinations or managing them carefully under medical supervision helps ensure lansoprazole works safely and effectively.